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2pf4

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Template:STRUCTURE 2pf4

Contents

Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit

Template:ABSTRACT PUBMED 17608567

Function

[2AAA_MOUSE] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis (By similarity).

About this Structure

2pf4 is a 8 chain structure with sequence from Mus musculus and Simian virus 40. Full crystallographic information is available from OCA.

Reference

  • Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W. Structural basis of PP2A inhibition by small t antigen. PLoS Biol. 2007 Aug;5(8):e202. PMID:17608567 doi:10.1371/journal.pbio.0050202

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OCA

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