3zpr

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Template:STRUCTURE 3zpr

Contents

Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound

Template:ABSTRACT PUBMED 23517028

Function

[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

About this Structure

3zpr is a 2 chain structure with sequence from Meleagris gallopavo. Full crystallographic information is available from OCA.

Reference

  • Christopher J, Brown J, Dore A, Errey J, Koglin M, Marshall FH, Myszka D, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. Biophysical fragment screening of the beta1-adrenergic receptor: Identification of high affinity aryl piperazine leads using structure-based drug design. J Med Chem. 2013 Mar 21. PMID:23517028 doi:10.1021/jm400140q

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OCA

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