4gr3

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Template:STRUCTURE 4gr3

Contents 1 Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A 2 Function 3 About this Structure 4 Reference

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A

Template:ABSTRACT PUBMED 23343195

Function

[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

About this Structure

4gr3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Czarny B, Stura EA, Devel L, Vera L, Lajeunesse E, Beau F, Calderone V, Fragai M, Luchinat C, Dive V. Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies. J Med Chem. 2013 Jan 23. PMID:23343195 doi:10.1021/jm301574d