4fx9

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Template:STRUCTURE 4fx9

Contents

Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase

Template:ABSTRACT PUBMED 23530771

Function

[CDR_PYRHO] Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo.

About this Structure

4fx9 is a 2 chain structure with sequence from Pyrococcus horikoshii ot3. Full crystallographic information is available from OCA.

Reference

  • Herwald S, Liu AY, Zhu BE, Sea KW, Lopez KM, Sazinsky MH, Crane Iii EJ. Characterization of the structure and substrate specificity of the pyrococcal CoADR/Psr: Implications for S0-based respiration and a sulfur-dependent antioxidant system in Pyrococcus. Biochemistry. 2013 Mar 26. PMID:23530771 doi:10.1021/bi3014399

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