4g59

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4g59

Contents 1 Crystal structure of the murine cytomegalovirus MHC-I homolog m152 with ligand RAE-1 gamma 2 Function 3 About this Structure 4 Reference

Crystal structure of the murine cytomegalovirus MHC-I homolog m152 with ligand RAE-1 gamma

Template:ABSTRACT PUBMED 23169621

Function

[RAE1C_MOUSE] Acts as a ligand for NKG2D.^[1]

About this Structure

4g59 is a 4 chain structure with sequence from Murid herpesvirus 1 and Mus musculus. Full crystallographic information is available from OCA.

Reference

• Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1gamma reveals a paradigm for MHC/MHC interaction in immune evasion. Proc Natl Acad Sci U S A. 2012 Nov 19. PMID:23169621 doi:10.1073/pnas.1214088109

1. ↑ Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 2000 Jun;12(6):721-7. PMID:10894171