Glutamate racemase (GR) catalyzes the racemization of L-glutamate to D-glutamate. GR plays a major role in bacterial cell wall biosynthesis and moonlights as gyrase inhibitor. GR inhibition is used as anti-bacterial target.
3D Structures of glutamate racemase
Updated on 24-June-2013
1b73, 1b74 – GR – Aquifex pyrophilus
2gzm, 2dwu – GR – Bacillus anthracis
2ohg, 2oho – SpGR – Streptococcus pyogenes
3hfr – LmGR – Listeria monocytogenes
3uhp – CjGR – Campylobacter jejuni
Glutamate racemate complexes
2jfn – GR + UDP-acetylmuramoyl-alanine + glutamate – Escherichia coli
2jfo, 2jfp – EfGR + D-glutamate – Enterococcus faecalis
2jfq – GR + D-glutamate – Staphylococcus aureus
3out – GR + D-glutamate – Francisella tularensis
3uhf, 3uho – CjGR + D-glutamate
2jfu – EfGR + phosphate
2jfv – EfGR + citrate
2jfw – EfGR + tartrate
2vvt – EfGR + inhibitor
3ist – LmGR + succinate
3isv – LmGR + acetate
2jfx, 2jfy – HpGR + D-glutamate – Helicobacter pylori
2jfz, 2w4i, 4b1f – HpGR + D-glutamate + inhibitor
2ohv – SpGR + D-glutamate derivative inhibitor
