Elastase

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Crystal structure of full-length human elastase (Metalloproteinase-12), 3ba0

Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative elastase structure, i.e. the human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA (3ba0). Calcium ions are shown as green balls, zinc ions are grey balls and acetohydroxamic acid is shown as space filling object. For additional details see Serine Proteases.

1 3D structures of elastase
2 MMP12
3 MMP16
4 ELA
5 ELA2

3D structures of elastase

Updated on 26-June-2013

MMP12

Matrix metalloproteinase

MMP16

Matrix metalloproteinase

ELA

3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est, 2oqu, 3odd, 3odf – pELA1 – pig
3hgn – pELA1+peptidyl inhibitor – neutron
3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est, 6est - pELA1+peptidyl inhibitor
1fzz – pELA1+ONO-6818
1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor
1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam
1eai – pELA1+Ascaris inhibitor
2d26 – pELA1+α-1-antitrypsin
1fle – pELA1+elafin
1b0e, 1b0f – pELA1+MDL
2v35 – pELA1+JM54
2iot – pELA1+clavulanic acid
2de9 – pELA1+tris
1uvo, 1uvp, 1lka, 1lkb – pELA1+ions
1gwa – pELA1+I3
1uo6, 1c1m – pELA1+Xe
1l0z, 1l1g - pELA1+Xe+Br
2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7
2bda – pELA1+N-acetyl-NPI
1mcv – pELA1+squash inhibitor
1bma – pELA1+aminimide
1elf, 1elg – pELA1+peptidyl hydroxylamine
1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor
1esa, 1esb – pELA1 intermediate
1eas, 1eat, 1eau – pELA1+pyridine inhibitor
1inc – pELA1+benzoxazinone
1jim, 9est, 8est – pELA1+coumarin derivative
2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent
3dbk – PaELA+phophoramidon – Pseudomonas aeruginosa
1u4g – PaELA+HPI
1ezm - PaELA
1elt – ELA - salmon

ELA2

3q76 – hELA2
3q77 – hELA2+dihydropyrimidone inhibitor
2z7f – hELA2 peptidase domain +antileukoproteinase
2rg3 – hELA2+sulfonic inhibitor
1h1b, 1ppg, 1hne – hELA2+inhibitor
1ppf – hELA2+ovomucoid
1b0f – hELA2+MDL101146