CD1 (or Cluster of Differentiation 1) is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.
3D Structures of CD1
Updated on 26-June-2013
CD1d
3gmq, 1cd1 – mCD1 extracellular domain + β-microglobulin - mouse
CD1 complex with glycolipid
1z5l – mCD1 extracellular domain + β-microglobulin + decahexne + octahexane
1zhn – mCD1 extracellular domain + β-microglobulin + phosphatidyl choline
2akr – mCD1 extracellular domain + β-microglobulin + sulfatide
2fik – mCD1 extracellular domain + β-microglobulin + glycosphingolipid
2gaz, 3ilp, 3ilq, 3t1f – mCD1 extracellular domain + β-microglobulin + lipoglycan
2q7y – mCD1 extracellular domain + β-microglobulin + IGB3
3gml, 3gmm, 3gmn, 3gmo, 3gmp, 3gmr – mCD1 extracellular domain + β-microglobulin + octadecane
3g08 – mCD1 extracellular domain + β-microglobulin + ceramide
3ma7 – mCD1 extracellular domain + β-microglobulin + cardiolipin
1z5l – mCD1 extracellular domain + β-microglobulin + ganglioside
CD1 complex with glycolipid and T-cell receptor protein
3he6, 3he7, 3o8x, 3o9w, 3arb, 3ard, 3are, 3arf, 3arg, 3qux, 3quy, 3quz, 3rug, 3rzc, 3scm, 3sda, 3sdc, 3sdd, 3ta3, 3tn0, 3to4, 3tvm, 3qi9, 3rtq – mCD1 extracellular domain + β-microglobulin + glycolipid + T-cell receptor NKT
4ei5, 4elm, 4apq – mCD1 extracellular domain + β-microglobulin + sulfatide + T-cell receptor NKT
3ubx – mCD1 extracellular domain + β-microglobulin + glycolipid+ antibody
