3v53
From Proteopedia
Contents |
Crystal structure of human RBM25
Template:ABSTRACT PUBMED 23190262
Function
[RBM25_HUMAN] RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.[1]
About this Structure
3v53 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gong D, Yang F, Li F, Qian D, Wu M, Shao Z, Wu M, Wu J, Shi Y. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. Biochem J. 2012 Nov 28. PMID:23190262 doi:10.1042/BJ20121382
- ↑ Zhou A, Ou AC, Cho A, Benz EJ Jr, Huang SC. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Mol Cell Biol. 2008 Oct;28(19):5924-36. doi: 10.1128/MCB.00560-08. Epub 2008 Jul , 28. PMID:18663000 doi:10.1128/MCB.00560-08
