This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1cwo
From Proteopedia
Contents |
HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
Template:ABSTRACT PUBMED 9769217
Function
[PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
About this Structure
1cwo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mikol V, Taylor P, Kallen J, Walkinshaw MD. Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A. J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217 doi:10.1006/jmbi.1998.2109
