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3t3d
From Proteopedia
Contents |
Glycogen phosphorylase b in complex with GlcU
Template:ABSTRACT PUBMED 22267166
Function
[PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
About this Structure
3t3d is a 1 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
- Kantsadi AL, Hayes JM, Manta S, Skamnaki VT, Kiritsis C, Psarra AM, Koutsogiannis Z, Dimopoulou A, Theofanous S, Nikoleousakos N, Zoumpoulakis P, Kontou M, Papadopoulos G, Zographos SE, Komiotis D, Leonidas DD. The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b. ChemMedChem. 2012 Jan 20. doi: 10.1002/cmdc.201100533. PMID:22267166 doi:10.1002/cmdc.201100533
