4gx9

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Template:STRUCTURE 4gx9

Contents 1 Crystal structure of a DNA polymerase III alpha-epsilon chimera 2 Function 3 About this Structure 4 Reference

Crystal structure of a DNA polymerase III alpha-epsilon chimera

Template:ABSTRACT PUBMED 23580545

Function

[DPO3E_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

About this Structure

4gx9 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

• Ozawa K, Horan NP, Robinson A, Yagi H, Hill FR, Jergic S, Xu ZQ, Loscha KV, Li N, Tehei M, Oakley AJ, Otting G, Huber T, Dixon NE. Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits alpha, {varepsilon}, theta and beta reveals a highly flexible arrangement of the proofreading domain. Nucleic Acids Res. 2013 Apr 10. PMID:23580545 doi:10.1093/nar/gkt162