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3ut9

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Revision as of 08:08, 30 June 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 3ut9

Contents

Crystal Structure of Nucleosome Core Particle Assembled with a Palindromic Widom '601' Derivative (NCP-601L)

Template:ABSTRACT PUBMED 22453276

Function

[H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

About this Structure

3ut9 is a 10 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Chua EY, Vasudevan D, Davey GE, Wu B, Davey CA. The mechanics behind DNA sequence-dependent properties of the nucleosome. Nucleic Acids Res. 2012 Mar 26. PMID:22453276 doi:10.1093/nar/gks261

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OCA

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