4jlt

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Template:STRUCTURE 4jlt

Contents

Crystal structure of P450 2B4(H226Y) in complex with paroxetine

Template:ABSTRACT PUBMED 23633618

Function

[CP2B4_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.

About this Structure

4jlt is a 1 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  • Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States. J Pharmacol Exp Ther. 2013 Jul;346(1):113-20. doi: 10.1124/jpet.113.204776. Epub , 2013 Apr 30. PMID:23633618 doi:10.1124/jpet.113.204776

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