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CD47

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Revision as of 06:46, 1 July 2013 by Michal Harel (Talk | contribs)

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Image:2jjs.png

Crystal structure of hCD47 residues 19-136 (mutant) complex with SIRP α 2jjs

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CD47 (Cluster of Differentiation 47) is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested.