3sbk

From Proteopedia

Revision as of 07:09, 3 July 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 3sbk

Contents

Russell's viper venom serine proteinase, RVV-V (PPACK-bound form)

Template:ABSTRACT PUBMED 21871889

Function

[VSPG_DABSI] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.[1]

About this Structure

3sbk is a 1 chain structure with sequence from Daboia russellii siamensis. Full crystallographic information is available from OCA.

Reference

  • Nakayama D, Ben Ammar Y, Miyata T, Takeda S. Structural basis of coagulation factor V recognition for cleavage by RVV-V. FEBS Lett. 2011 Aug 23. PMID:21871889 doi:10.1016/j.febslet.2011.08.022
  1. ↑ Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W. The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences. J Biol Chem. 1988 Nov 25;263(33):17471-81. PMID:3053712

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3sbk"
Personal tools