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3roq

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Revision as of 10:15, 3 July 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 3roq

Contents

Crystal structure of human CD38 in complex with compound CZ-46

Template:ABSTRACT PUBMED 22142305

Function

[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

About this Structure

3roq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kwong AK, Chen Z, Zhang H, Leung FP, Lam CM, Ting KY, Zhang L, Hao Q, Zhang LH, Lee HC. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry. 2011 Dec 14. PMID:22142305 doi:10.1021/bi201509f

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OCA

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