3cow

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Template:STRUCTURE 3cow

Contents 1 Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.^[1]

About this Structure

3cow is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

See Also

• Pantothenate synthetase

Reference

• Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem. 2008 Nov 3;9(16):2606-11. PMID:18821554 doi:10.1002/cbic.200800437

1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627