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3cfs
From Proteopedia
Contents |
Structural basis of the interaction of RbAp46/RbAp48 with histone H4
Template:ABSTRACT PUBMED 18571423
Function
[RBBP7_HUMAN] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.[1]
About this Structure
3cfs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008 Jul;16(7):1077-85. Epub 2008 Jun 19. PMID:18571423 doi:http://dx.doi.org/10.1016/j.str.2008.05.006
- ↑ Zhang Q, Vo N, Goodman RH. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol Cell Biol. 2000 Jul;20(14):4970-8. PMID:10866654
Categories: Homo sapiens | Ben-Shahar, T R. | Laue, E D. | Luisi, B F. | Murzina, N V. | Pei, X-Y. | Pratap, J V. | Sparkes, M. | Verreault, A. | Vicente-Garcia, J. | Chaperone | Chromatin | Chromatin regulator | Chromosomal protein | Dna replication | Histone | Histone-chaperone complex | Nucleosome core | Nucleus | Phosphoprotein | Rbap46/rbap48 | Repressor | Transcription | Transcription regulation | Wd repeat | Wd-40 repeat protein
