3tk9

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Template:STRUCTURE 3tk9

Contents 1 Crystal structure of human granzyme H 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of human granzyme H

Template:ABSTRACT PUBMED 22156497

Function

[GRAH_HUMAN] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.^{[1] [2]}

About this Structure

3tk9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Granzyme

Reference

• Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z. Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif. J Immunol. 2011 Dec 9. PMID:22156497 doi:10.4049/jimmunol.1101381

1. ↑ Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z. Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif. J Immunol. 2011 Dec 9. PMID:22156497 doi:10.4049/jimmunol.1101381
2. ↑ Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542