4is8

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Template:STRUCTURE 4is8

Contents

Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors

Template:ABSTRACT PUBMED 23737522

Function

[NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

About this Structure

4is8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. J Biol Chem. 2013 Jun 4. PMID:23737522 doi:10.1074/jbc.M113.472837

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OCA

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