1f1j

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spinqualitylabelsall models PDB ID 1f1j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1f1j, resolution 2.35Å ()
Ligands:
Non-Standard Residues:	,
Structural annotation: Resources: CATH : 1F1Ja00, 1F1Jb00 InterPro : Ipr001309, Ipr011600, Ipr016129, Ipr015917, Ipr015471, Ipr002398, Ipr002138 Pfam : PF00656 SCOP : d1f1ja_, d1f1jb_
Evolutionary conservation: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO 2 Function 3 About this Structure 4 See Also 5 Reference

CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO

Template:ABSTRACT PUBMED 10873833

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

1f1j is a 4 chain structure with sequence from Homo sapiens. The August 2004 RCSB PDB Molecule of the Month feature on Caspases by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_8. Full crystallographic information is available from OCA.

See Also

• Caspase

Reference

• Wei Y, Fox T, Chambers SP, Sintchak J, Coll JT, Golec JM, Swenson L, Wilson KP, Charifson PS. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity. Chem Biol. 2000 Jun;7(6):423-32. PMID:10873833