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4eaz

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Template:STRUCTURE 4eaz

Contents

Vgll1-TEAD4 structure

Template:ABSTRACT PUBMED 22632831

Function

[VGLL1_MOUSE] May act as a specific coactivator for the mammalian TEFs (By similarity). [TEAD4_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.

About this Structure

4eaz is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pobbati AV, Chan SW, Lee I, Song H, Hong W. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831 doi:10.1016/j.str.2012.04.004

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