4fgu
From Proteopedia
Contents |
Crystal structure of prolegumain
Template:ABSTRACT PUBMED 23776206
Function
[LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
About this Structure
4fgu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Dall E, Brandstetter H. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc Natl Acad Sci U S A. 2013 Jun 17. PMID:23776206 doi:10.1073/pnas.1300686110
