4kpq

From Proteopedia

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Template:STRUCTURE 4kpq

Contents 1 Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6 2 Function 3 About this Structure 4 Reference

Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6

Template:ABSTRACT PUBMED 23760233

Function

[HEMA_I77AF] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

About this Structure

4kpq is a 6 chain structure with sequence from Influenza a virus (a/gull/maryland/704/1977(h13n6)). Full crystallographic information is available from OCA.

Reference

• Lu X, Qi J, Shi Y, Wang M, Smith DF, Heimburg-Molinaro J, Zhang Y, Paulson JC, Xiao H, Gao GF. Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6. J Virol. 2013 Jun 12. PMID:23760233 doi:10.1128/JVI.00235-13