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4k7q

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Template:STRUCTURE 4k7q

Contents

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

Template:ABSTRACT PUBMED 23673416

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

About this Structure

4k7q is a 1 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC. Crystal structure of AcrB complexed with linezolid at 3.5 A resolution. J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x., Epub 2013 May 15. PMID:23673416 doi:10.1007/s10969-013-9154-x
  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

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