4jep

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Template:STRUCTURE 4jep

Contents

Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)

Template:ABSTRACT PUBMED 23526564

Function

[NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).

About this Structure

4jep is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

  • Krug U, Totzauer R, Strater N. The crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 represents a conformational intermediate in the reductive activation mechanism of the tetrameric enzyme. Proteins. 2013 Mar 22. doi: 10.1002/prot.24288. PMID:23526564 doi:10.1002/prot.24288

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