4gve

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Template:STRUCTURE 4gve

Contents

Tacaribe nucleoprotein structure

Template:ABSTRACT PUBMED 23615902

Function

[NCAP_TACVF] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses (By similarity).

About this Structure

4gve is a 1 chain structure with sequence from Tacaribe virus strain franze-fernandez. Full crystallographic information is available from OCA.

Reference

  • Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression. J Biol Chem. 2013 Apr 24. PMID:23615902 doi:10.1074/jbc.M112.420521

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OCA

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