4fvx

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Template:STRUCTURE 4fvx

Contents

Structure of rat nNOS heme domain in complex with N(omega)-ethoxy-L-arginine

Template:ABSTRACT PUBMED 23586781

Function

[NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

About this Structure

4fvx is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Jansen Labby K, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB. Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction. Biochemistry. 2013 May 7;52(18):3062-73. doi: 10.1021/bi301571v. Epub 2013 Apr, 26. PMID:23586781 doi:10.1021/bi301571v

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