3u3q

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3u3q

Contents 1 The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6) 2 Function 3 About this Structure 4 Reference

The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)

Template:ABSTRACT PUBMED 22525750

Function

[TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

About this Structure

3u3q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ. S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750 doi:10.1107/S0907444912004490