3s8e

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Template:STRUCTURE 3s8e

Contents 1 Phosphorylation regulates assembly of the caspase-6 substrate-binding groove 2 Function 3 About this Structure 4 See Also 5 Reference

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

Template:ABSTRACT PUBMED 22483120

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

About this Structure

3s8e is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Caspase

Reference

• Velazquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure. 2012 Apr 4;20(4):742-51. Epub 2012 Apr 3. PMID:22483120 doi:10.1016/j.str.2012.02.003