3sir

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Template:STRUCTURE 3sir

Contents 1 Crystal Structure of drICE 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of drICE

Template:ABSTRACT PUBMED 21811237

Function

[ICE_DROME] Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.

About this Structure

3sir is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

• Caspase

Reference

• Li X, Wang J, Shi Y. Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun. 2011 Aug 2;2:408. doi: 10.1038/ncomms1418. PMID:21811237 doi:10.1038/ncomms1418