2if4

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Image:2if4.gif

2if4, resolution 2.85Å

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Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana

Overview

FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

About this Structure

2IF4 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters., Granzin J, Eckhoff A, Weiergraber OH, J Mol Biol. 2006 Dec 8;364(4):799-809. Epub 2006 Sep 26. PMID:17045295

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