3zl1

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Template:STRUCTURE 3zl1

Contents

A thiazolyl-mannoside bound to FimH, monoclinic space group

Template:ABSTRACT PUBMED 23795713

Function

[FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.

About this Structure

3zl1 is a 2 chain structure with sequence from Escherichia coli j96. Full crystallographic information is available from OCA.

Reference

  • Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG. Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients. J Med Chem. 2013 Jun 24. PMID:23795713 doi:10.1021/jm400723n

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