4ga7

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Template:STRUCTURE 4ga7

Contents

Crystal structure of human serpinB1 mutant

Template:ABSTRACT PUBMED 23269243

Function

[ILEU_HUMAN] Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.[1]

About this Structure

4ga7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542
  1. ↑ Cooley J, Takayama TK, Shapiro SD, Schechter NM, Remold-O'Donnell E. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry. 2001 Dec 25;40(51):15762-70. PMID:11747453

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