2m10

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Template:STRUCTURE 2m10

Contents 1 trans form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative 2 Function 3 About this Structure 4 Reference

trans form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative

Template:ABSTRACT PUBMED 23818626

Function

[PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.^[1]

About this Structure

2m10 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Buchli B, Waldauer SA, Walser R, Donten ML, Pfister R, Blochliger N, Steiner S, Caflisch A, Zerbe O, Hamm P. Kinetic response of a photoperturbed allosteric protein. Proc Natl Acad Sci U S A. 2013 Jul 1. PMID:23818626 doi:10.1073/pnas.1306323110

1. ↑ Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20. PMID:15611135 doi:10.1074/jbc.M412211200