3j42

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Template:STRUCTURE 3j42

Contents

Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody

Template:ABSTRACT PUBMED 23740974

Function

[Q3BCY5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

About this Structure

3j42 is a 12 chain structure with sequence from Dengue virus 2, Gekko coi and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Wang Z, Li L, Pennington JG, Sheng J, Yap ML, Plevka P, Meng G, Sun L, Jiang W, Rossmann MG. Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody. J Virol. 2013 Jun 5. PMID:23740974 doi:10.1128/JVI.00472-13

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