4bd9

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Template:STRUCTURE 4bd9

Contents 1 Structure of the complex between SmCI and human carboxypeptidase A4 2 Function 3 About this Structure 4 Reference

Structure of the complex between SmCI and human carboxypeptidase A4

Template:ABSTRACT PUBMED 23746805

Function

[CBPA4_HUMAN] Metalloprotease that could be involved in the histone hyperacetylation pathway.^[1]

About this Structure

4bd9 is a 2 chain structure with sequence from Homo sapiens and Sabellastarte magnifica. Full crystallographic information is available from OCA.

Reference

• Alonso Del Rivero M, Reytor ML, Trejo SA, Chavez MA, Aviles FX, Reverter D. A Noncanonical Mechanism of Carboxypeptidase Inhibition Revealed by the Crystal Structure of the Tri-Kunitz SmCI in Complex with Human CPA4. Structure. 2013 Jul 2;21(7):1118-26. doi: 10.1016/j.str.2013.04.021. Epub 2013, Jun 6. PMID:23746805 doi:10.1016/j.str.2013.04.021

1. ↑ Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 1999 Jun 15;59(12):2981-8. PMID:10383164