4kk0

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Template:STRUCTURE 4kk0

Contents

Crystal Structure of TSC1 core domain from S. pombe

Function

[TSC1_SCHPO] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.[1] [2] [3]

About this Structure

4kk0 is a 10 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.

Reference

  1. ↑ Matsumoto S, Bandyopadhyay A, Kwiatkowski DJ, Maitra U, Matsumoto T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics. 2002 Jul;161(3):1053-63. PMID:12136010
  2. ↑ van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem. 2004 Mar 26;279(13):12706-13. Epub 2004 Jan 12. PMID:14718525 doi:10.1074/jbc.M313874200
  3. ↑ Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, Ohnuki M, Hiraoka Y, Matsumoto T. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006 Jun;173(2):569-78. Epub 2006 Apr 19. PMID:16624901 doi:10.1534/genetics.106.056895

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