2wbe

From Proteopedia

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Template:STRUCTURE 2wbe

Contents 1 Kinesin-5-Tubulin Complex with AMPPNP 2 Function 3 About this Structure 4 See Also 5 Reference

Kinesin-5-Tubulin Complex with AMPPNP

Template:ABSTRACT PUBMED 19285086

Function

[TBA1A_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. [TBB_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

About this Structure

2wbe is a 3 chain structure with sequence from Bos taurus and Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

• Kinesin
• Tubulin

Reference

• Bodey AJ, Kikkawa M, Moores CA. 9-Angstrom structure of a microtubule-bound mitotic motor. J Mol Biol. 2009 May 1;388(2):218-24. Epub 2009 Mar 10. PMID:19285086 doi:10.1016/j.jmb.2009.03.008