3c06

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Template:STRUCTURE 3c06

Contents 1 Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1 2 Function 3 About this Structure 4 See Also 5 Reference

Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1

Template:ABSTRACT PUBMED 21696158

Function

[TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.

About this Structure

3c06 is a 1 chain structure with sequence from Lactobacillus casei. Full crystallographic information is available from OCA.

See Also

• Thymidylate synthase

Reference

• Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67. Epub 2011 Jul 12. PMID:21696158 doi:10.1021/jm2005018