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1v00
From Proteopedia
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ERYTHRINA CRISTAGALLI LECTIN
Overview
Erythrina cristagalli lectin (ECL) is a galactose-specific legume lectin., Although its biological function in the legume is unknown, ECL exhibits, hemagglutinating activity in vitro and is mitogenic for T lymphocytes. In, addition, it has been recently shown that ECL forms a novel conjugate when, coupled to a catalytically active derivative of the type A neurotoxin from, Clostridium botulinum, thus providing a therapeutic potential. ECL is, biologically active as a dimer in which each protomer contains a, functional carbohydrate-combining site. The crystal structure of native, ECL was recently reported in complex with lactose and 2'-fucosyllactose., ECL protomers adopt the legume lectin fold but form non-canonical dimers, via the handshake motif as was previously observed for Erythrina, ... [(full description)]
About this Structure
1V00 is a [Single protein] structure of sequence from [Eukaryota] with LAT, MN and CA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:15201215
Page seeded by OCA on Tue Oct 30 16:17:03 2007
Categories: Eukaryota | Single protein | Acharya, K.R. | Chaddock, J.A. | Natesh, R. | Thiyagarajan, N. | Turton, K. | CA | LAT | MN | Carbohydrate-binding | Lectin | Non-canonical dimer
