3j0b

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Template:STRUCTURE 3j0b

Contents

cryo-EM reconstruction of West Nile virus

Template:ABSTRACT PUBMED 23602814

Function

[Q9Q6P4_WNV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]

About this Structure

3j0b is a 3 chain structure with sequence from West nile virus. Full crystallographic information is available from OCA.

Reference

  • Zhang W, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG. Membrane curvature in flaviviruses. J Struct Biol. 2013 Apr 18. pii: S1047-8477(13)00100-7. doi:, 10.1016/j.jsb.2013.04.005. PMID:23602814 doi:10.1016/j.jsb.2013.04.005

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