4k6l

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Template:STRUCTURE 4k6l

Contents

Structure of Typhoid Toxin

Template:ABSTRACT PUBMED 23842500

Function

[CDTB_SALTI] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.

About this Structure

4k6l is a 7 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhi. Full crystallographic information is available from OCA.

Reference

  • Song J, Gao X, Galan JE. Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500 doi:10.1038/nature12377

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