3vie

From Proteopedia

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Template:STRUCTURE 3vie

Contents 1 HIV-gp41 fusion inhibitor Sifuvirtide 2 Function 3 About this Structure 4 See Also 5 Reference

HIV-gp41 fusion inhibitor Sifuvirtide

Template:ABSTRACT PUBMED 22228771

Function

[Q9YP39_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).

About this Structure

3vie is a 6 chain structure. Full crystallographic information is available from OCA.

See Also

• Gp41

Reference

• Yao X, Chong H, Zhang C, Waltersperger S, Wang M, Cui S, He Y. Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide. J Biol Chem. 2012 Feb 24;287(9):6788-96. Epub 2012 Jan 6. PMID:22228771 doi:10.1074/jbc.M111.317883