2g6q

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Template:STRUCTURE 2g6q

Contents

Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide

Template:ABSTRACT PUBMED 16728977

Function

[ING2_MOUSE] Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).

About this Structure

2g6q is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature. 2006 Jul 6;442(7098):100-3. Epub 2006 May 21. PMID:16728977 doi:10.1038/nature04814

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