4ijo

From Proteopedia

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Template:STRUCTURE 4ijo

Contents 1 Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases 2 Function 3 About this Structure 4 Reference

Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases

Template:ABSTRACT PUBMED 23583775

Function

[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

About this Structure

4ijo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Udi Y, Fragai M, Grossman M, Mitternacht S, Arad-Yellin R, Calderone V, Melikian M, Toccafondi M, Berezovsky IN, Luchinat C, Sagi I. Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases. J Mol Biol. 2013 Apr 11. pii: S0022-2836(13)00240-4. doi:, 10.1016/j.jmb.2013.04.009. PMID:23583775 doi:10.1016/j.jmb.2013.04.009