2m5v

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Template:STRUCTURE 2m5v

Contents 1 Three-dimensional structure of human NLRP10/PYNOD pyrin domain 2 Function 3 About this Structure 4 Reference

Three-dimensional structure of human NLRP10/PYNOD pyrin domain

Template:ABSTRACT PUBMED 23861819

Function

[NAL10_HUMAN] Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.^{[1] [2] [3]}

About this Structure

2m5v is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Su MY, Kuo CI, Chang CF, Chang CI. Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue. PLoS One. 2013 Jul 4;8(7):e67843. doi: 10.1371/journal.pone.0067843. Print 2013. PMID:23861819 doi:10.1371/journal.pone.0067843

1. ↑ Wang Y, Hasegawa M, Imamura R, Kinoshita T, Kondo C, Konaka K, Suda T. PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Int Immunol. 2004 Jun;16(6):777-86. Epub 2004 Apr 19. PMID:15096476 doi:10.1093/intimm/dxh081
2. ↑ Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J Immunol. 2010 May 15;184(10):5874-84. doi: 10.4049/jimmunol.0900779. Epub 2010 , Apr 14. PMID:20393137 doi:10.4049/jimmunol.0900779
3. ↑ Lautz K, Damm A, Menning M, Wenger J, Adam AC, Zigrino P, Kremmer E, Kufer TA. NLRP10 enhances Shigella-induced pro-inflammatory responses. Cell Microbiol. 2012 Oct;14(10):1568-83. doi: 10.1111/j.1462-5822.2012.01822.x., Epub 2012 Jun 21. PMID:22672233 doi:10.1111/j.1462-5822.2012.01822.x