4kk0

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Template:STRUCTURE 4kk0

Contents

Crystal Structure of TSC1 core domain from S. pombe

Template:ABSTRACT PUBMED 23857276

Function

[TSC1_SCHPO] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.[1] [2] [3]

About this Structure

4kk0 is a 10 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.

Reference

  • Sun W, Zhu YJ, Wang Z, Zhong Q, Gao F, Lou J, Gong W, Xu W. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun. 2013 Jul 16;4:2135. doi: 10.1038/ncomms3135. PMID:23857276 doi:10.1038/ncomms3135
  1. ↑ Matsumoto S, Bandyopadhyay A, Kwiatkowski DJ, Maitra U, Matsumoto T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics. 2002 Jul;161(3):1053-63. PMID:12136010
  2. ↑ van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem. 2004 Mar 26;279(13):12706-13. Epub 2004 Jan 12. PMID:14718525 doi:10.1074/jbc.M313874200
  3. ↑ Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, Ohnuki M, Hiraoka Y, Matsumoto T. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006 Jun;173(2):569-78. Epub 2006 Apr 19. PMID:16624901 doi:10.1534/genetics.106.056895

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