4bji

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Template:STRUCTURE 4bji

Contents 1 Sfc1-DBD 2 Function 3 About this Structure 4 Reference

Sfc1-DBD

Function

[SFC1_SCHPO] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.^{[1] [2]}

About this Structure

4bji is a 1 chain structure with sequence from Schizosaccharomyces pombe 927. Full crystallographic information is available from OCA.

Reference

1. ↑ Huang Y, Hamada M, Maraia RJ. Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta. J Biol Chem. 2000 Oct 6;275(40):31480-7. PMID:10906331 doi:10.1074/jbc.M004635200
2. ↑ Noma K, Cam HP, Maraia RJ, Grewal SI. A role for TFIIIC transcription factor complex in genome organization. Cell. 2006 Jun 2;125(5):859-72. PMID:16751097 doi:10.1016/j.cell.2006.04.028